Table 5.

Comparison of SNPs found significant in prior Carlson et al.^a study with current, non-overlapping sample.

SNP	Seattle SNP annotation	Carlson coefficient (±SE)	Carlson t-Statistic b	Carlson P c	Current coefficient (±SE)d	Current t-Statistic b	Current P c
rs854566e	PON16842	−10.6  (±4.3)	−2.480	0.014	−20.4  (±4.68)	−4.353	1.64 × 10 − 5
rs3917510	PON112471	16.6  (±6.9)	2.424	0.016	14.3  (±6.48)	2.208	0.028
rs2269829	PON119470	−16.5  (±10.8)	−1.520	0.129	13.6  (±21.82)	0.625	0.533
rs3917564	PON123887	−39.0  (±18.1)	−2.153	0.032	15.0  (±26.67)	0.564	0.573
rs854549	PON129021	9.2  (±4.5)	2.051	0.041	−1.3  (±4.90)	−0.260	0.795
rs854572	PON1895	13.0  (±4.9)	2.677	0.008	−0.28  (±4.97)	−0.056	0.955

SE = standard error.

^aCarlson et al. study n = 500 European male subjects [27].

^b t-Statistics and P-values were calculated from the coefficients from each subgroup (Carlson n = 500, current study n = 523) and standard errors within the best-fit multivariate model by the glm function in R.

^cBoth Carlson and current study utilized a linear regression model adjusting for age, current smoking status, and the four functional PON1 SNPs.

^dCurrent study subset of 523 European male subjects not considered by Carlson et al.

^eRepresented by proxy SNP, rs854457, with LD r ² = 0.93 in the current study.