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. Author manuscript; available in PMC: 2012 May 31.
Published in final edited form as: Anticancer Agents Med Chem. 2011 Oct;11(8):729–738. doi: 10.2174/187152011797378689

Figure 2. Regulated transgene expression from the therapeutic adenoviral vectors.

Figure 2

Ad-mediated regulated therapeutic cytotoxin expression. Ad.mhIL-4.TRE.mhIL-13-PE expresses mhIL-4 and mhIL-13-PE under the control of the bidirectional TRE promoter, which is activated by rtTA2sM2 in the presence of Dox (ON state, A). In the absence of the inducer (OFF state, B) the transactivator is unable to induce transgene expression.