Table 2.
Effects of zolpidem (100 nM, 1 μM, and 10 μM) on uIPSCs recorded from Imp paired recordings experiments.
uIPSCs | Control (n = 6) | zolpidem (100 nM, n = 6) | zolpidem (1 μM, n = 6) | zolpidem (10 μM, n = 6) | wash (n = 3) |
---|---|---|---|---|---|
peak amplitude (pA) | −27.1 ± 9.5 | −27.3 ± 9.5 | −25.1 ± 7.9 | −27.5 ± 9.0 | −29.0 ± 17.4 |
Rise time | 1.3 ± 0.2 | 1.3 ± 0.1 | 1.4 ± 0.2 | 1.8 ± 0.3* | 1.1 ± 0.3 |
Decay time (ms) | 18.6 ± 2.9 | 19.7 ± 2.6 | 21.0 ± 2.8 | 29.3 ± 4.4 | 18.2 ± 1.8 |
Data are expressed as mean ± SEM; n = number of recorded pairs; two-tailed Wilcoxon-signed ranks test was used for comparison between pre- and post-zolpidem values (
P < 0.05).