Figure 2.

Representation of the IL8 promoter region and the mutations used in this study, as indicated by the underlined nucleotides. mAP-1: mutation of AP-1. mNFκB: mutation of NFκB and mCEBP: mutation of CEBP binding site. Functional effect of site-directed mutagenesis of transcription factor binding sites in the IL8 promoter in primary human myometrial cells. Data are presented as mean ± SEM (n = 4). An Anova test was performed with a Dunnett's multiple comparison post-test. **indicates a significant difference of P less than 0.01 compared to WT promoter.