Fig. 7.
R9LF-2 is metabolically stable LF inhibitor and has better protection than R9LF-1. (a) Spectra of MALDI-TOF indicate that R9LF-2 is stable to LF. R9LF-2 (50 μM) was incubated with LF (10 μM) for different period of time and the conversion of the inhibitor was monitored by MALDI-TOF MS. (b) Comparison of the protection of LF induced cell death byR9LF-1 and R9LF-2. J774A.1 cells were challenged by LT in the presence of R9LF-1 or R9LF-2 (30 μM). Living cells were measured by CCK-8. Error bars represent results of more than three independent experiments.
