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. 2012 Jun;62(3):166–171.

Figure 2.

Figure 2.

At the gene expression level, the oxidative stress response of UD wounds resembles that in normal wound healing. mRNA levels for oxidative stress response genes in UD and normally wounded mice were measured by qualitative PCR and normalized to hypoxanthine–guanine phosphoribosyltransferase (Hprt). Expression levels are shown as fold change (mean ± 1 SD) as compared with controls. HO1 is depicted separately, due to the larger scale. (A) C57BL/6 UD-wounded mice compared with C57BL/6 controls (6 wounded compared with 11 control mice for Gpx1, Prdx1, SOD1, and SOD2; 6 wounded compared with 5 control mice for Cat, Prdx6, and HO1). (B) SOD1 and SOD2 expression in C57BL/6 normally wounded animals compared with C57BL/6 controls (6 wounded compared with 6 control mice). (C) SOD1 and SOD2 expression in BALB/cHsd normally wounded animals compared with BALB/cHsd controls (7 wounded compared with 6 control mice). For all comparisons, statistical analyses were performed on log-transformed expression levels (see Methods). *, P < 0.05, †, P < 0.01 compared with levels in corresponding controls.