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. Author manuscript; available in PMC: 2012 Nov 15.
Published in final edited form as: J Immunol. 2012 Apr 13;188(10):5032–5040. doi: 10.4049/jimmunol.1200349

FIGURE 7.

FIGURE 7

S1PR1-signalling blockade displaces marginal zone B cells from the splenic marginal zone. MADCAM1-expressing sinus-lining cells (green) form a distinct barrier between the marginal zone (MZ) and the white pulp (WP) (brown, arrows). In the spleens of control (C57BL/6) mice (A, left hand panel) and control (Cre-deficient) mice (B, left-hand panel), abundant CD1d-expressing marginal zone B cells (red) were present within the marginal zone and B cell follicles (FO). FTY720 treatment (A, right-hand panels) or B cell-restricted S1PR1-deficiency in CD19cre S1PR1flox/flox mice (B, right-hand panels) caused the displacement of marginal zone B cells into the B cell follicles. Data are representative of tissues from 4-6 mice/group. RP, red pulp. Scale bar = 100 μm.