Table 1.
The common enhancer genes that potentiated the effect of topotecan from three screens
| Genes that enhance the effect of topotecan-induced cell death | ||||||
|---|---|---|---|---|---|---|
| BIRC4 *, ** | BOK * | BBC3 | CNTF | ICEBERG | PDCD2 | TNFAIP1 |
| CTSD *, ** | CDKN2A * | BCL11B | DAP | IGF1 | PIK3C2G | TNFAIP2 |
| NFKB1 *, ** | CDKN2D * | BCL2A1 | DNASE1 | IL10RB | PRDX5 | TNFSF12 |
| NOS2A *, ** | F2R * | BIRC3 | DOCK1 | IL1B | PRF1 | TNFSF5 |
| RIPK1 *, ** | MCL1 * | BNIP3 | DUSP7 | LTB | PTGS1 | TP53 |
| TGFB1 *, ** | MMP9 * | CARD10 | ERCC6 | MAP2K6 | RAD23B | TRAF1 |
| TNFRSF10A *, ** | STK3 * | CARD14 | FAF1 | MAP3K14 | RB1 | TRAF6 |
| TNFRSF25 *, ** | TNFRSF10D * | CASP9 | GPX1 | MYB | SFRP5 | WDR3 |
| TNFRSF8 *, ** | TP53BP2 * | CLU | HSPE1 | NOS3 | TIA1 | YWHAZ |
Footnote: *genes present in the second screen (18); ** genes in all three screens (9)