Table 2.
Covariates and RRM1 or ERCC1 (Patient N, row%)
| RRM1 Expression | ERCC1 Expression | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RRM1 mRNA expression (PCR) | RRM1 protein expression (IHC) | ERCC1 mRNA expression (PCR) | ERCC1 protein expression (IHC) | |||||||||||||
| Covariate | High | Low | N | p | High | Low | N | p | High | Low | N | p | High | Low | N | p |
| Age (years) | ||||||||||||||||
| Young (<65.5) | 4 (21%) | 15 (79%) | 49 | 1.0 | 14 (30%) | 32 (70%) | 93 | 0.51 | 19 (48%) | 21 (53%) | 79 | 0.36 | 29 (62%) | 18 (38%) | 94 | 0.41 |
| Old (> 65.5) | 6 (20%) | 24 (80%) | 18 (38%) | 29 (62%) | 14 (36%) | 25 (64%) | 24 (51%) | 23 (49%) | ||||||||
| Size (cm) | ||||||||||||||||
| Small (<2.0) | 1 (9%) | 10 (91%) | 49 | 0.42 | 5 (26%) | 14 (74%) | 93 | 0.59 | 4 (31%) | 9 (69%) | 79 | 0.54 | 11 (55%) | 9 (45%) | 94 | 1.0 |
| Large (> 2.0) | 9 (24%) | 29 (76%) | 27 (36%) | 47 (64%) | 29 (44%) | 37 (56%) | 42 (57%) | 32 (43%) | ||||||||
| Gender | ||||||||||||||||
| Female | 6 (24%) | 19 (76%) | 49 | 0.73 | 14 (35%) | 26 (65%) | 93 | 1.0 | 13 (37%) | 22 (63%) | 79 | 0.50 | 25 (61%) | 16 (39%) | 94 | 0.53 |
| Male | 4 (17%) | 20 (83%) | 18 (34%) | 35 (66%) | 20 (45%) | 24 (55%) | 28 (53%) | 25 (47%) | ||||||||
| Race | ||||||||||||||||
| White | 4 (12%) | 29 (88%) | 48 | 0.11 | 23 (35%) | 43 (65%) | 92 | 1.0 | 22 (42%) | 31 (58%) | 78 | 1.0 | 36 (55%) | 30 (45%) | 93 | 0.82 |
| Non-White | 5 (33%) | 10 (67%) | 9 (35%) | 17 (65%) | 11 (44%) | 14 (56%) | 16 (59%) | 11 (41%) | ||||||||
| Histological Grade¥ | ||||||||||||||||
| 1 or 2 | 7 (19%) | 29 (81%) | 48 | 1.0 | 22 (30%) | 51 (70%) | 92 | 0.10 | 27 (45%) | 33 (55%) | 78 | 0.43 | 42 (57%) | 32 (43%) | 93 | 0.80 |
| 3 or 4 | 2 (17%) | 10 (83%) | 10 (53%) | 9 (47%) | 6 (33%) | 12 (67%) | 10 (53%) | 9 (47%) | ||||||||
| Lymph Nodes¥ | ||||||||||||||||
| No LN positive | 4 (31%) | 9 (69%) | 47 | 0.24 | 9 (35%) | 17 (65%) | 91 | 1.0 | 14 (64%) | 8 (36%) | 77 | 0.024 | 16 (59%) | 11 (41%) | 92 | 0.82 |
| At least 1 LN positive | 5 (15%) | 29 (85%) | 23 (35%) | 42 (65%) | 19 (35%) | 36 (65%) | 36 (55%) | 29 (45%) | ||||||||
| Depth of Tumor (pT) ¥ | ||||||||||||||||
| T1 and T2 | 2 (20%) | 8 (80%) | 48 | 1.0 | 4 (27%) | 11 (73%) | 92 | 0.56 | 4 (36%) | 7 (64%) | 78 | 0.75 | 5 (33%) | 10 (67%) | 93 | 0.087 |
| T3 and T4 | 7 (18%) | 31 (82%) | 28 (36%) | 49 (64%) | 29 (43%) | 38 (57%) | 47 (60%) | 31 (40%) | ||||||||
¥ The difference in values corresponds to the patients with metastatic disease only, for whom some variables were not able to be computed.