Table 5.
Overall and Disease-Free Survival using Kaplan-Meier and log-rank test but only in patients who received complete chemotherapy regimen (all of whom received gemcitabine)
| Overall Survival | Disease-Free Survival | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Covariate | Median [months] (95% CI) | N | Total N | Log-rank p-value |
Median [months] (95% CI) | N | Total N | Log-rank p-value |
|
| Overall | 20.3 (15, 25.5) | 82 | 82 | 13.5 (9.3, 19.4) | 62 | 62 | |||
| Age | Young (≤ 65.5) | 22 (15.6, 47.2) | 44 | 82 | 0.18 | 10.5 (8, 19.3) | 38 | 62 | 0.48 |
| Old (> 65.5) | 17 (9.6, 25.5) | 38 | 14 (8, ∞) | 24 | |||||
| Size | Small (≤ 2.0) | 25 (9.6, 47.2) | 18 | 82 | 0.45 | 20.5 (8.3, ∞) | 12 | 62 | 0.21 |
| Large (> 2.0) | 17.7 (14.8, 25.5) | 64 | 12 (8, 17.3) | 50 | |||||
| Gender | Female | 22 (14.8, 34.5) | 36 | 82 | 0.85 | 10 (6.5, 17.3) | 31 | 62 | 0.12 |
| Male | 20 (14.4, 25.5) | 46 | 19.3 (9.4, 46) | 31 | |||||
| Race | White | 20 (14.8, 26.5) | 59 | 82 | 0.88 | 13.5 (8, 25.5) | 42 | 62 | 0.65 |
| Non-White | 22 (9.2, 26.2) | 23 | 10.3 (5.5, 592) | 20 | |||||
| Grade | 1/2 | 20.5 (16, 25.5) | 67 | 82 | 0.028 | 14 (10.3, 20.5) | 51 | 62 | 0.0503 |
| 3/4 | 14.5 (6.5, 26.5) | 15 | 9.4 (2, 25.5) | 11 | |||||
| Lymph Nodes | 0 | 25.5 (15, 48.5) | 26 | 81 | 0.038 | 20.5 (13.5, ∞) | 20 | 61 | 0.012 |
| ≥ 1 | 16 (13, 20.3) | 55 | 9.4 (6.5, 14) | 41 | |||||
| Tumor | 1/2 | 20 (6.5, 47) | 13 | 82 | 0.59 | 19.5 (5.5, ∞) | 8 | 62 | 0.21 |
| (TNM) | 3/4 | 20.5 (15, 26) | 69 | 12 (8, 19.3) | 54 | ||||
| RRM1 | Low | 20.3 (15, 25.5) | 55 | 81 | 0.87 | 13.5 (8, 20.5) | 39 | 61 | 0.84 |
| IHC Interp | High | 47.8 (8.7, 48) | 26 | 16.6 (5.5, ∞) | 22 | ||||
| RRM1 | Low | 24 (17, 26) | 37 | 44 | 0.070 | 14 (9.4, 25.5) | 26 | 32 | 0.62 |
| PCR Interp | High | 48 (*, *) | 7 | 17.3 (10.5, 17.3) | 6 | ||||
| ERCC | Low | 20.3 (14.8, 26.5) | 35 | 82 | 0.88 | 14 (9.4, 31.5) | 25 | 62 | 0.36 |
| IHC Interp | High | 17 (13.3, 26) | 47 | 12 (6.5, 20.5) | 37 | ||||
| ERCC | Low | 17 (14.5, 24.7) | 39 | 68 | 0.23 | 10 (7, 25.5) | 28 | 54 | 0.74 |
| PCR Interp | High | 24 (11, 63.7) | 29 | 13.5 (8, 20.5) | 26 | ||||
* The 95% confidence interval could not be estimated since only one event (death) was recorded.