Table 1. Predicted binding affinities and experimental .

				Predicted *
Anesthetic	Binding Site	()	()	()	()
Isoflurane	Pore(closed)	2.9	83	2.8–86	60
Isoflurane	Pore(open)	620	530	370–890	60
Isoflurane	Allosteric	2,800
Propofol	Pore(closed)	0.46	1.8	0.38–2.1	24
Propofol	Pore(open)	1.5	2.9	1.1–4.0	24
Propofol	Allosteric	9.4
Ethanol	Pore(closed)	7.1

Binding affinities based on free energies presented in Table 2.

*: Range of predicted corresponds to model parameter varying from 0 (higher ) to 1 (lower ).