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. 2012 May 31;8(5):e1002534. doi: 10.1371/journal.pcbi.1002534

Figure 5. Thermodynamic phase diagrams of RNA replication.

Figure 5

A–B: The Inline graphic-Inline graphic diagrams with color levels and contours (black dashed lines) representing Inline graphic (A) and Inline graphic (B). The black solid lines show the spinodal terminated by the critical point (filled circles). The red solid lines show the L-C transition for Inline graphic and Inline graphic, which meets the spinodal at the triple point (open circles). The white dashed lines show the boundary of Inline graphic region (smaller Inline graphic side). The green dashed lines show the analogous region of Inline graphic values for starvation processes (Inline graphic). The vertical lines show the location of the nonenzymatic Inline graphic value. C–D: The Inline graphic-Inline graphic and Inline graphic-Inline graphic diagrams. The green dashed lines represent the Inline graphic boundary. The blue dotted lines give the maximum and minimum Inline graphic and Inline graphic, respectively, and the red dotted line in D denotes the maximum error rate at equilibrium. The fitness Inline graphic is in units of Inline graphic.