Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 May 31;7(5):e38149. doi: 10.1371/journal.pone.0038149

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Urich et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

( A ) All genes for mouse BECs versus hCMEC/D3 are displayed as grey dots. Tight junction genes (red square), SLC members (blue dot), ABC members (yellow triangle) and the surface receptors (green diamond) are highlighted. The x-axis shows the ratio between mouse and hCMEC/D3 and the y-axis shows the ratio between mouse BECs and hCMEC/D3 multiplied by the expression levels in mouse BECs. Genes in the upper right corner are therefore highly expressed in mouse BECs and much more in comparison to the hCMEC/D3 cell line. The graph shows that all key BBB genes are expressed at lower levels in the human cell line hCMEC/D3 (enlarged symbols). A similar result was obtained when comparing the mouse expression data to the hpBECs. ( B ) A schematic representation of the key genes identified in this study to have low level of expression in the hCMEC/D3 cells. The picture illustrates the spatial location of the BBB genes on BECs and the fold reduction in expression compared to mouse BECs.