Figure 3. State-dependency is impaired in GluA1−/− mice in morphine-conditioned place preference.

(A) Time spent in the morphine-associated zone during 15 min (900 s). Animals were tested either in Sal-state (priming injection of saline) or in Mor10-state (priming injection of 10 mg/kg morphine). (B) Distance moved during the 15 min preference test. Data represent means ± SEM, n = 8–33. ^* p<0.05, ^*** p<0.001, between the genotypes, t-test; ^$ p<0.05, ^$$ p<0.01, ^$$$ p<0.001, between testing states, t-test; ^# p<0.05, ^## p<0.01, between conditioning doses, compared to saline control, Bonferroni test; ^& p<0.05, between conditioning doses, compared to morphine 10 mg/kg conditioning dose, Bonferroni test. Sal = Saline, Mor = Morphine.