Table 1. EC50 and maximal stimulation values for DAMGO stimulation of GTPγ[35S] binding in various brain regions of GluA1+/+ and GluA1−/− mice.
| Region | EC50 | Maximal stimulation | ||
| GluA1+/+ | GluA1−/− | GluA1+/+ | GluA1−/− | |
| Caudate-putamen | 0.45±0.07 | 0.44±0.09 | 394±18 | 337±23 |
| Nucleus accumbens | 0.65±0.17 | 0.45±0.11 | 414±8 | 383±28 |
| Thalamus | 0.41±0.07 | 0.43±0.09 | 293±14 | 294±21 |
| Amygdala | 0.41±0.07 | 0.29±0.11 | 235±13 | 245±15 |
| Hypothalamus | 0.47±0.12 | 0.26±0.06 | 183±8 | 197±8 |
| Substantia nigra reticulata | 0.91±0.32 | 0.69±0.15 | 181±19 | 176±7 |
| Ventral tegmental area | 1.20±0.29 | 1.35±0.49 | 254±12 | 224±22 |
| Periaqueductal gray | 0.87±0.25 | 0.38±0.09 | 176±14 | 198±10 |
| Inferior colliculus | 1.03±0.31 | 0.63±0.17 | 276±18 | 290±21 |
| Locus coeruleus | 0.59±0.33 | 0.38±0.12 | 174±15 | 177±10 |
Values are mean ± SEM, n = 5–7, in µM for EC50 values and as percentage of basal for maximal stimulation.