Table 2. Diagnostic test accuracy of newly described CDR.

	Number of patients	Number of episodes	Age of patients	Outcome	Number with poor outcome	Proportion in low risk group	Sensitivity	Specificity
Hakim [16]	332	332	Median 6 yrs, range 2.4 months to 21.6 years	Serious infection or sepsis	47	69%	74.5% (95% CI 60.5% to 84.7%)	76.4% (95% CI 71.1% to 81.1%)
				Medical complications	40	63.7%	77.5% (95% CI 62.5% to 87.7%)	69.5% (95% CI 63.9% to 74.5%)
Delebarre [14](abstract only)	146	316	Mean age 8 years, range 0.5 yrs to 17.5 yrs		70	20.6%	98.6% (95% CI 92.3% to 99.7%)	26% (95% CI 20.9% to 31.8%)
Badiei [17], Threshold value: 0 risk factors	68	120	Mean 5.9 years	Life threatening infection	35	29.2%	97.1% (95% CI 85.5% to 99.5%)	40% (95% CI 30.2% to 50.6%)
1 risk factor					35	64.2%	71.4% (95% CI 54.9% to 83.7%)	78.8% (95% CI 69% to 86.2%)
2 risk factors					35	75%	62.9% (95% CI 46.3% to 76.8%)	90.6% (95% CI 82.5% to 95.2%)
3 risk factors					35	85%	40% (95% CI 25.6% to 56.4%)	95.3% (95% CI 88.5% to 98.2%)
4 risk factors					35	98.3%	5.7% (95% CI 1.6% to 18.6%)	100% (95% CI 95.7% to 100%)
SPOG [7] (Adverse events rule)	206	423	6.9 years (IQR 3.8 years to 11.6 years)	Serious adverse medical outcome	122	35%	92% (IQR 91% to 93%, range 90% to 98%)	45% (IQR, 38% to 49%, range 12% to 57%)
SPOG [18] (Bacteraemia rule)				Late bacteraemia	67	36%	93% (IQR 91% to 97%)	41% (IQR 21% to 45%)

CI = confidence intervals; IQR = interquartile range.