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. 2012 May 31;7(5):e37304. doi: 10.1371/journal.pone.0037304

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Hagemann et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Compared to wild-type mice, Gfap mutant mice show elevated Iba1 immunoreactivity in hippocampus either with or without Nrf2. (B) Western analysis of hippocampal protein shows reduced Iba1 expression in Gfap^+/R236H/Nrf2^−/− compared with Gfap^+/R236H/Nrf2^+/+ mice (8 wks), although levels remain elevated above wild-type (**p<0.01, unpaired t-test comparing Gfap^+/R236H/Nrf2^+/+ with Gfap^+/R236H/Nrf2^−/− mice, n = 4). Lanes 5 and 6 for Nrf2^−/− samples are from a different region of the same gel as lanes 1–4 (Nrf2^+/+ samples).