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The TPR-like motif and L571 of NCT are important for γ-secretase activity. (A–D) NCT−/− cells were transiently cotransfected with mNΔE and cDNAs encoding NCT or various NCT mutants. Upper: Steady-state expression of NCT and NCT variants. Lower: Full-length mNΔE substrate and γ-secretase–generated NICD fragments. The identities of NCT variants are indicated.
