Figure 4.
Structural similarities between transcription factors and histone proteins. (Upper) Heterotetrameric assembly of the N-terminal portions of two Drosophila TAFIIs (dTAFII42/dTAFII62)2 (60), and the corresponding view of the histone H3/H4 heterotetramer derived from the structure of the histone octamer (61) (the additional N-terminal helix of H3 visualized in this study has been omitted for clarity). (Lower) The DNA binding domain of hepatocyte nuclear factor-3γ (62), and the corresponding view of the globular domain of the linker histone H5 (GH5) (63).