Fig. 1.

Dominant structures for the PCNA/FEN1/DNA and 9Δ-1-1/FEN1/DNA complexes from MD trajectory clustering analysis. The (A) PCNA and (B) 9Δ-1-1 complex are shown as cartoons. PCNA is shown in green, FEN1 in purple, Rad1 in green, Hus1 in yellow, Rad 9 in blue, and DNA in black. The gray surfaces are the FEN1/DNA from the original starting models. The surfaces for the two clamps in the starting models were omitted for clarity. (C and D) Computed B-factors mapped onto the PCNA and 9Δ-1-1 models. Coloring corresponds to computed B-factor values from high (red) to low (blue). (Insets) Highlight of the B-factor difference for upstream DNA as it passes through the two clamps.