Table 1.

Indication for molecular testing based on clinical features of the individual’s family history of cancer by the German consortium for hereditary breast and ovarian cancer (GC-HBOC)

Number of affected relatives	Indication for performing DNA-analysis
1
a	BC ≤ 35 years
b	Bilateral BC ≤ 50 years
c	BC and OC
d	BC/OC and male BC in the family
2
a	Two cases of BC/OC, one case <51 years
b	Two cases OC
c	One case BC and one case OC
3
a	Three cases of BC