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. 2012 May 29;2(5):e122. doi: 10.1038/tp.2012.44

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Copyright © 2012 Macmillan Publishers Limited

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Tph2 expression and serotonin synthesis in Tph2^−/− mice. (a) RT–PCR analysis of Tph2 expression in the brain. AU, arbitrary units. ^**P<0.01, Student's t-test. (b) 5-HT level in the whole brain (HPLC measurement). Tph2^+/+ 5-HT level is taken as 100%. (c) 5-HTP level in the whole brain 1 h after NSD administration (100 mg kg^–1, intraperitoneally) (HPLC measurement). Tph2^+/+ 5-HTP level is taken as 100%. Data are shown as means±s.e.m., n=6. ^***P<0.001, ^**P<0.01 vs Tph2^+/+; ^§§§P<0.001 vs Tph2^+/−, one-way ANOVA with Bonferroni correction. ANOVA, analysis of variance; HPLC, high-performance liquid chromatography; 5-HT, 5-hydroxytryptamine; 5-HTP, 5-hydroxytryptophan.

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