Figure 2.

Locomotor activity and anxiety-like behavior in Tph2^−/− mice. Open field: (a) Total distance traveled. Elevated plus maze: (b) Activity: total number of entries to closed and open arms. (c) Percentage of entries to open arms: entries to open arm/total arm entries. (d) Total time spent in open arms. Marble burying test: (e) Percentage of buried marbles: buried/introduced amount of marbles. (f) Locomotor activity during MBT. Novelty supressed feeding: (g) Latency to feed. (h) Consumed amount of food during 5 min after reaching the food pellet. (a–f): Tph2^−/− n=10, Tph2^+/− and Tph2^+/+ n=12; (g, h): Tph2^−/− n=11, Tph2^+/− n=13, Tph2^+/+ n=10. Data are shown as means±s.e.m. ^**P<0.01, ^*P<0.05 vs Tph2^+/+; ^§§§P<0.001, ^§§P<0.01, ^§P<0.05 vs Tph2^+/−, one-way ANOVA with Bonferroni correction. ANOVA, analysis of variance.