Table 3. Repeated measures analysis of covariance in schizophrenia patients and healthy controls for change in Δ13CO2 and CRR during the 120 min L-[1-13C]phenylalanine breath test.
| Parameter | Patients (n=20) | Controls (n=20) | Repeated measures ANCOVAa | |
|---|---|---|---|---|
| Mean±s.d. | Mean±s.d. | F | P | |
| Δ13CO2 | ||||
| Δ13CO2 at 10 min (‰) | 6.8±6.8 | 10.2±7.3 | ||
| Δ13CO2 at 15 min (‰) | 9.6±7.9 | 15.5±8.6 | ||
| Δ13CO2 at 20 min (‰) | 11.5±7.9 | 15.9±6.7 | ||
| Δ13CO2 at 30 min (‰) | 10.1±5.6 | 13.1±4.6 | ||
| Δ13CO2 at 45 min (‰) | 7.4±3.4 | 8.7±2.5 | ||
| Δ13CO2 at 60 min (‰) | 5.7±2.5 | 6.9±2.0 | ||
| Δ13CO2 at 90 min (‰) | 3.8±1.6 | 4.6±1.6 | ||
| Δ13CO2 at 120 min (‰) | 2.7±1.3 | 3.2±1.1 | ||
| Interactionb | 2.55 | 0.091 | ||
| Between group | 4.57 | 0.039 | ||
| CRR | ||||
| CRR at 10 min (%) | 0.5±0.5 | 0.8±0.5 | ||
| CRR at 15 min (%) | 1.2±1.1 | 1.8±1.1 | ||
| CRR at 20 min (%) | 2.0±1.6 | 3.0±1.5 | ||
| CRR at 30 min (%) | 3.7±2.5 | 5.2±2.1 | ||
| CRR at 45 min (%) | 5.8±3.3 | 7.8±2.6 | ||
| CRR at 60 min (%) | 7.3±3.8 | 9.6±2.9 | ||
| CRR at 90 min (%) | 9.5±4.6 | 12.3±3.5 | ||
| CRR at 120 min (%) | 11.0±5.1 | 14.1±4.0 | ||
| Interactionb | 4.73 | 0.033 | ||
| Between group | 4.87 | 0.034 | ||
Abbreviations: ANCOVA, analysis of covariance; CRR, the cumulative recovery rate.
a
Repeated measures analysis of covariance with age and body weight as covariates.
b
Interaction between diagnostic status and sampling point.