Figure 7.

Serum S100B predicts neurologic deficit and correlates with the correction gradient of serum sodium in osmotic demyelination syndrome. (A) shows that early neuropathological manifestations and death are associated with higher S100B concentrations after correction with hypertonic saline (P < 0.001 by Wilcoxon signed-rank test for matched pairs). (B) S100B levels correlated with the neurologic manifestations (n = 42, r = −0.51, P = 0. 0012) and the gradient of serum sodium. (C) n = 42, r = 0.45, P = 0.0035 by Spearman correlation. (D) Serum S100B levels were elevated 24 hours postcorrection in rats that achieved a gradient greater than 23 mEq/L/24 hours (P < 0.0001 by Wilcoxon signed-rank test for matched pairs), whereas no changes were seen in rats with a gradient less than 23 mEq/L/24 hours (n = 11 for the low gradient group and n = 31 for the high gradient group).