Figure 5. Diabetic mellitus is a disorder with disintegrated body clocks occurring through the lack of insulin sensitivity.
The liver, muscle, adipose tissue, brain, and lung were harvested at ZT4: 16 each from control and STZ-induced rats. STZ-induced rats were injected with insulin (50 U·mg−1·kg−1) and killed 2 h after the injection for measurement of mRNA levels. Per2 mRNA levels were determined by RT-PCR. Values and bars represent mean ± SEM of 6 control or STZ-induced rats. The statistical significance of differences of differences among values was analyzed ANOVA and then by Duncan's multiple range test. Values with different letters indicate a statistically significant difference (p < 0 .05).