Table 4.

Example of contingency table for TF HNF3 alpha overrepresentation test.

Number of HNF3 alpha binding sites altered by any mutations	Number of all, excluding HNF3 alpha binding sites, altered by any mutations
Number of HNF3 alpha binding sites not altered by mutations	Number of all, excluding HNF3 alpha binding sites, not altered by mutations

The obtained p-values were corrected for multiplicity testing using Bonferroni method. The significance threshold of 0.05 was used. In the use of GeneMANIA we report the p-values generated by the tool and determine statistical significance using 0.05 as the threshold value.