FIG. 4.

Contribution of diet and other NOS isoforms to the depletion of NO metabolites in eNOS^−/− mice. Data are from eNOS^−/− animals (n=9) kept on a standard rodent chow, and eNOS^−/− kept on a low NOx diet without (n=5) and with additional L-NIO treatment (n=3). Left-hand panels show steady-state concentrations in individual compartments (individual changes in nitrosothiol, nitrosamine and NO-heme concentrations can be found in Supplementary Fig. 2 online), right-hand panels display a theoretical total body concentration for each NO metabolite pool, expressed as a weighted average. Data are mean±SEM, *p<0.05.