FIG. 5.

Changes in NO metabolite levels upon dietary NOx restriction and chronic NOS inhibition in Wistar rats. Animals were kept either on standard rodent chow (control), low-NOx diet/MilliQ water (for 14 days), or low-NOx diet/MilliQ water for 7 days followed by low-NOx diet/L-NMMA in MilliQ water for another week. Left-hand panels show steady-state concentrations in individual compartments, right-hand panels display a theoretical total body concentration for each NO metabolite pool expressed as a weighted average. Data are means±SEM of 3–5 animals/group, *p<0.05. Glutathione and ascorbate measurements were carried out in a parallel set of animals treated in an identical manner (n=3/group).