. 2010 Jul 28;1(1-2):25–44. doi: 10.1007/s13148-010-0006-2

Table 1.

Histone deacetylases

Class HDAC	HDACs yeast	HDACs mammalian	Length	Mechanism of deacetylation	Tissue expression
Class I	RPD3	HDAC1	482	Zn²⁺ dependent	Ubiquitous
		HDAC2	488
		HDAC3	428
		HDAC8	377
Class II	HDA1	HDAC4	1084	Zn²⁺ dependent	Restricted
		HDAC5	1122
		HDAC6	1215
		HDAC7	912
		HDAC9	1011
		HDAC10	669
Class III	SIR2	SIRT1	747	NAD⁺ dependent	ND
	HST1	SIRT2	373
	HST2	SIRT3	399
	HST3	SIRT4	314
	HST4	SIRT5	310
		SIRT6	355
		SIRT7	400
Class IV	RPD3	HDAC11	347	Zn²⁺ dependent	Ubiquitous