Fig. 1.

Small antisense RNA-directed transcriptional gene silencing—a de novo derived small antisense RNAs, designed to target a promoter of choice, can interact with promoter-associated RNAs at the transcribed promoter (Hawkins et al. 2009; Han et al. 2007) and facilitate the recruitment of epigenetic remodeling complexes (Weinberg et al. 2006; Turner et al. 2009; Hawkins et al. 2009; Han et al. 2007; Kim et al. 2006; Suzuki et al. 2005; Suzuki et al. 2008). b The result of small antisense RNA targeting is the epigenetic remodeling and stable silencing of transcription from the targeted promoter