Table 2.
Arterial Pco2, Po2, and MAP during baseline and 90 min posthypoxia
| PaCO2, mmHg |
PaO2, mmHg |
MAP, mmHg |
||||
|---|---|---|---|---|---|---|
| Experimental Groups | Baseline | 90 min | Baseline | 90 min | Baseline | 90 min |
| Severe | 49.2 ± 1.7 | 49.2 ± 1.6 | 280 ± 34abcd | 323 ± 3e | 127 ± 9cd | 125 ± 7cd |
| Severe + MSX-3 | 47.5 ± 1.1 | 47.1 ± 1.1 | 335 ± 3 | 298 ± 26ae | 109 ± 6 | 113 ± 6 |
| Severe + methysergide | 51.7 ± 1.2ab | 51.5 ± 1.3ab | 335 ± 7 | 326 ± 5 | 107 ± 10 | 91 ± 14be |
| Moderate | 47.5 ± 0.8 | 47.4 ± 0.9 | 336 ± 4 | 329 ± 4 | 122 ± 6 | 117 ± 5 |
| Moderate + MSX-3 | 48.6 ± 0.5c | 49.0 ± 0.4c | 330 ± 7 | 324 ± 6 | 103 ± 7a | 99 ± 5a |
| Moderate + methysergide | 52.1 ± 0.7ab | 52.3 ± 0.7ab | 333 ± 9 | 321 ± 3 | 108 ± 9 | 83 ± 8ae |
| Vehicle (−AIH) | 46.9 ± 1.3 | 47.0 ± 1.1 | 329 ± 7 | 322 ± 3 | 110 ± 7 | 101 ± 8 |
| MSX-3 (−AIH) | 45.1 ± 1.5 | 45.2 ± 1.4 | 331 ± 3 | 326 ± 3 | 101 ± 4 | 106 ± 7 |
| Methysergide (−AIH) | 51.2 ± 1.7 | 50.7 ± 2.0 | 326 ± 7 | 324 ± 3 | 119 ± 9 | 94 ± 10e |
Values are expressed as means ±1 SE. Significant difference from
a
moderate AIH alone,
b
severe + MSX-3,
c
appropriate time control group (−AIH)),
d
severe + methysergide, and
e
from baseline. Differences were considered significant if P < 0.05.