Fig. 1.

Ethanol intoxication-withdrawal program. Young adult male rats completed two cycles of consuming control dextrin or 6.5% ethanol diet for 4 wk, followed by 3 wk of ethanol withdrawal (EW). Intermittant hypoxia (IH) conditioning was applied during the last 3 days of the first ethanol diet and the first 17 days of subsequent EW. Rats were tested for overt signs of acute EW 24 h after the termination of the second ethanol diet, and recovered for 6 days before undergoing 5 days of Rotarod testing. Rats were killed at 3 wk of the second EW period, and cerebelli were harvested for biochemical analyses.