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A model of RNP degradation. In mRNP degradation, mRNPs are disassembled by RNA helicases (Upf1 in NMD). This RNP disassembly step is essential for mRNA degradation by RNases. During ribosomal degradation, E3 ubiquitin ligase first ubiquitinates the ribosomal proteins. Using these ubiquitins as tags, the Cdc48 complex promotes the dissociation of the 40S subunit. The proteasome degrades key protein(s) from the 60S particles and then triggers the initiation of RNA decay.
