Table 3.
Significant predictors of involved margins and second operation/no second operation calculated by logistic regression for cases undergoing breast conservation (wide local excision) as their first surgical treatment (n=87)
| Characteristic | Clear margins (n=46) | Involved margins (n=41) | Odds ratio (95% confidence interval) | p-value* | No further surgery (n=53) | Further surgery (n=34) | Odds ratio (95% confidence interval) | p-value* | |
|---|---|---|---|---|---|---|---|---|---|
| Mammographic size of DCIS (mm) | 0.9–9.9 | 9 (20%) | 9 (22%) | 12 (23%) | 6 (18%) | ||||
| 10.0–19.9 | 17 (37%) | 9 (22%) | 20 (38%) | 6 (18%) | |||||
| 20.0–29.9 | 12 (26%) | 14 (34%) | 14 (26%) | 12 (35%) | 1.07 (1.01–1.21) | p=0.008 | |||
| 30.0–39.9 | 5 (11%) | 5 (12%) | 5 (9%) | 5 (15%) | |||||
| 40+ | 3 (7%) | 3 (7%) | 2 (4%) | 4 (12%) | |||||
| BI-RADS®a | 1 | 5 (11%) | 3 (7%) | 6 (11%) | 2 (6%) | ||||
| 2 | 21 (46%) | 15 (37%) | 23 (43%) | 13 (38%) | |||||
| 3 | 17 (37%) | 19 (46%) | 21 (40%) | 15 (44%) | |||||
| 4 | 3 (7%) | 4 (10%) | 3 (6%) | 4 (12%) | |||||
| R scoreb | 1 | 1 (2%) | 0 (0%) | 1 (2%) | 0 (0%) | ||||
| 2 | 2 (4%) | 2 (5%) | 3 (6%) | 1 (3%) | |||||
| 3 | 12 (26%) | 11 (27%) | 11 (21%) | 12 (35%) | |||||
| 4 | 7 (15%) | 12 (30%) | 3.29 (1.03–10.53) | p=0.045 | 12 (23%) | 7 (21%) | |||
| 5 | 23 (50%) | 12 (30%) | 24 (45%) | 11 (32%) | |||||
| Location of radiological abnormality | LIQ | 10 (22%) | 4 (10%) | 8 (15%) | 6 (18%) | 0.15 (0.30–0.76) | p=0.022 | ||
| LOQ | 10 (22%) | 4 (10%) | 12 (23%) | 2 (6%) | |||||
| SAR | 1 (2%) | 2 (5%) | 2 (4%) | 1 (3%) | |||||
| UIQ | 7 (15%) | 7 (17%) | 11 (21%) | 3 (9%) | |||||
| UOQ | 18 (39%) | 24 (59%) | 20 (38%) | 22 (65%) | |||||
| Asymmetric density | No | 42 (91%) | 37 (90%) | 48 (91%) | 31 (91%) | ||||
| Yes | 2 (4%) | 4 (10%) | 3 (6%) | 3 (9%) | |||||
| Stromal deformity | No | 43 (94%) | 41 (100%) | 50 (94%) | 34 (100%) | ||||
| Yes | 1 (2%) | 0 (0%) | 1 (2%) | 0 (0%) | |||||
| Microcalcification | No | 2 (4%) | 1 (2%) | 3 (6%) | 0 (0%) | ||||
| Yes | 42 (91%) | 40 (98% | 48 (91%) | 34 (100%) | |||||
| Distribution of microcalcification | Cluster | 20 (44%) | 11 (27%) | 24 (45%) | 7 (21%) | ||||
| Diffuse | 0 (0%) | 1 (2%) | 0 (0%) | 1 (3%) | 0.26 (0.09–0.77) | p=0.015 | |||
| Segmental | 14 (30%) | 18 (44%) | 15 (28%) | 17 (50%) | |||||
| Missing data | 12 (26%) | 11 (27%) | 14 (26%) | 9 (27%) | |||||
| Associated mass | No | 40 (87%) | 36 (89%) | 44 (83%) | 32 (94%) | ||||
| Yes | 6 (13%) | 5 (12%) | 9 (17%) | 2 (6%) | |||||
| B scorec | 4 | 2 (4%) | 0 (0%) | 2 (4%) | 0 (0%) | ||||
| 5a | 43 (94%) | 41 (100%) | 50 (94%) | 34 (100%) | |||||
| Surgical margins | Clear of margins | 46 (100%) | 0 (0%) | 43 (81%) | 3 (9%) | 69.29 (16.03–299.43) | p<0.001 | ||
| At margin/uncertain | 0 (0%) | 41 (100%) | 10 (19%) | 31 91%) | |||||
| Oestrogen receptor status | Positive | 35 (76%) | 23 (56%) | 41 (77%) | 17 (50%) | ||||
| Negative | 10 (22%) | 17 (41%) | 2.59 (1.01–6.63) | p=0.048 | 10 (19%) | 17 (50%) | 4.10 (1.56–10.75) | p=0.004 | |
| Missing data | 1 (2%) | 1 (2%) | 2 (4%) | 0 (0%) | |||||
BI-RADS® = Breast Imaging Reporting and Data System; LIQ = lower inner quadrant; LOQ = lower outer quadrant; SAR = subareolar region; UIQ = upper inner quadrant; UOQ = upper outer quadrant
a
1 = almost entirely fat; 2 = scattered fibroglandular densities; 3 = heterogeneously dense; 4 = extremely dense
b
1 = normal; 2 = benign; 3 = probably benign; 4 = probably malignant; 5 = malignant
c
4 = indeterminate probably malignant; 5a = malignant (non invasive)
*
Variables where p-value is not stated were not significant.