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The known routes to Alzheimer disease
| Primary cause | Route | Final result |
|---|---|---|
| Down syndrome | More APP production | More Aβ42(43) and more Aβ40 |
| APP670/1 (Swedish) | Potentiation of β-secretase | More Aβ42(43) and more Aβ40 |
| APP692 (Flemish) | Inhibition of α-secretase | More Aβ42(43) |
| APP717 (London) | Alteration of site of γ-secretase cut | More Aβ42(43) |
| PS1 mutations | Subtle alteration of APP processing | More Aβ42(43) |
| PS2 mutations | Subtle alteration of APP processing | More Aβ42(43) |
