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. Author manuscript; available in PMC: 2013 Jun 15.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Apr 30;22(12):3921–3925. doi: 10.1016/j.bmcl.2012.04.112

Scheme 1.

Scheme 1

Reagents and conditions: (a) EDC, DMAP, DCM, DIPEA, 95%; (b) 20% CuI, 5% Pd(PPh3)4, 48 acetylenes (1.1 equiv.), DMF, DIEA, 60 °C, 1 h, 15-90%.