. Author manuscript; available in PMC: 2013 Jun 15.

Published in final edited form as: Bioorg Med Chem Lett. 2012 Apr 30;22(12):3921–3925. doi: 10.1016/j.bmcl.2012.04.112

Table 1.

Structures and Activities of Analogs 10.



Cmpd	NR₁R₂	plC₅₀^a ±SEM	IC₅₀ (μM)^a	%Glu Min^b ±SEM
7		5.42±0.04	3.8	10.4±2.1
10a		5.30±0.06	5.0	4.4±0.7
10b		5.61±0.07	2.5	−1.1±0.5
10c		5.24±0.01	5.7	2.2±1.1
10d			>10	16.4±2.5
10e		5.69±0.04	2.1	0.5±0.4
10f			>10	7.6±3.2
10g			>10	9.6±2.1

Measured in an mGlu3 GIRK assay.

% Glu Min is the % inhibition of the compound on an EC₈₀ concentration of glutamate. Values represent the mean ± standard error mean for three independent experiments performed in triplicate.