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Negishi Cross-couplings of Z- and Mixed Z/E-Alkenyl Halides.a
a Conditions: organozinc iodide (1.1 mmol, 1.0 M in THF), alkenyl halide (1 mmol), PdCl2(Amphos)2 (2 mol %). Isolated yields. Reactions were run at 0.33 M at rt for 24 h. Z/E-ratio determined by NMR and GC on crude material. b As available commercially. c As obtained from 4-MeO-cinnamic acid via Grob fragmentation.
