Table 5.
Characteristics of the 8 disease-free failure patients
| Case | Age | Stage | Tumor size (cm) |
Node+ | ER+ | Menopausal status |
Tumor location |
Margins | Chemo | Tam | Failure type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| A | 67 | I | 0.7 | No | Yes | Postmenopausal | LIQ | Neg | No | No | INF (axilla) DF |
| B | 73 | I | 1.7 | Yes | Yes | Surgical menopause | UOQ | Neg | No | Yes | DF Death (spine metastases) |
| C | 50 | I | 0.3 | No | Yes | Postmenopausal | UC | Neg | Yes, after XRT | No | IBF (outside field) Simple mastectomy |
| D | 80 | I | 1.3 | No | Yes | Postmenopausal | UIQ | Neg | No | Yes | INF (axilla) Bilateral mastectomy |
| E | 84 | I | 0.7 | No | NR | Postmenopausal | UOQ | Neg | No | No | IBF (within field, invasive) IBF (skin of treated breast) INF* (axilla), DF Death (liver metastases) |
| F | 70 | I | 1.4 | No | Yes | Postmenopausal | LOQ | Neg | No | No | Death (bladder, second primary) |
| G | 60 | I | 1.2 | No | NR | Surgical menopause | UOQ | Initially Pos | No | No | IBF (within field, invasive) Bilateral mastectomy |
| H | 53 | I | 0.6 | Yes | NR | Postmenopausal | UOQ | Neg | Yes, prior to XRT† | No | DF |
Abbreviations: IBF = ipsilateral breast failure; chemo = chemotherapy; ER = estrogen receptor status; DF = distant failure; INF = ipsilateral nodal failure; LOQ = lower inner quadrant; NR = not reported; tam = tamoxifen; UC = upper central; UIQ = upper inner quadrant; UOQ = upper outer quadrant; XRT = radiation therapy.
*
This failure met the protocol-specified criteria for INF.
†
202 days from surgery to radiation therapy.