Table 6.
Partial breast irradiation studies using external beam radiation
| Institution/series | No. cases | Follow-up (months) | Fractionation schedule |
IBF rate | Cosmetic result (good/excellent) |
≥Grade 3 toxicity |
|---|---|---|---|---|---|---|
| RTOG 0319 (current study) | 52 | 54 (median) | 385 cGy × 10 (b.i.d.) | 6% | NS | 4% |
| William Beaumont Hospital (8,29) | 94 | 50 (median) | 340 or 385 cGy × 10 (b.i.d.) | 1.1% | 89% | 4% |
| Harvard (31) | 99 | 36 | 3200 cGy 4 Gy/bid | 2% | 97% | NS |
| New York University/Keck School of Medicine (32) | 10 | 36 (minimum) | 500, 550, or 600 cGy × 5 (10 days) | 0% | 100% | NS |
| Formenti (15) | 47 | 18 (median) | 600 cGy × 5 (10 days) | 0% | NS | NS |
| Christie Hospital/ Holt Radium Institute (33) | 353 | 96 (mean) | 500–531 cGy × 8 (10 days) | 25% | NS† | NS |
| National Institute of Oncology, Hungary (Phase III Trial)* | 40 | 86 (median) | 200 cGy × 25 | 2.5% | 70% | NS |
| Rocky Mountain Cancer Center (34) | 55 | 34 | 385 cGy × 10 (b.i.d.) | 0% | NS | NS |
| NSABP B39/ RTOG 0413 Phase III Trial (28) | 3200 | 19.4 (mean) | 385 cGy × 10 (b.i.d.) | NS | NS | <1% |
| Hospital de la Esperanza Barcelona, Spain Phase III Trial (30) | 46 | 18 (median) | 375 cGy × 10 (b.i.d.) | 0% | NS | 0% |
| Tufts University Brown University (25) | 64 | 15 (median) | 385 cGy × 10 (b.i.d.) | NS | 81.7% | 8.3% |
| University of Michigan (26) | 34 | >24 | 385 cGy × 10 (b.i.d.) | NS | 79.5% | NS |
Abbreviations: b.i.d. = twice daily; IBF = ipsilateral breast failure; NS = not stated.
*
Personal communication.
†
Partial breast irradiation patients had a greater incidence of fibrosis, telangiectasias, and fat necrosis.