Figure 1.

Overview of coupling cycle times for one full iteration of solid phase synthesis on Kaiser oxime resin. Room temperature solid phase synthesis cycles are significantly slower (≥190 min) than microwave optimized conditions for N-methylpyrrole nucleophiles (25 min total) and N-methylimidazole nucleophiles (median 65 min total). Boxes are scaled to the time required for each step within a coupling cycle.