Skip to main content
. Author manuscript; available in PMC: 2012 Nov 11.
Published in final edited form as: Cell. 2012 May 3;149(4):912–922. doi: 10.1016/j.cell.2012.03.033

Figure 5. Model for SRGAP2 evolution.

Figure 5

Schematic depicts location and orientation (blue triangles) of SRGAP2 paralogs on human chromosome 1 with putative protein products indicated above each based on cDNA sequencing. Arrows trace the evolutionary history of SRGAP2 duplication events. Copy-number polymorphism and expression analyses suggest both paralogs at 1q21.1 (SRGAP2B and SRGAP2D) are pseudogenes, whereas the 1q32.1 (SRGAP2A) and 1p12 (SRGAP2C) paralogs are likely to encode functional proteins.