Table 1.
Characteristics of pediatric patients (age < 18 years) who underwent an unrelated bone marrow donor transplant receiving a myeloblative conditioning regimen, reported to CIBMTR between 1990 and 2003.
| Characteristics | N (%) |
|---|---|
| Number of patients | 638 |
| Age at transplant, median (range), years | 10 (<1-17.9) |
| Age at transplant, years | |
| <5 | 151 (24) |
| 6-10 | 183 (29) |
| 11-15 | 167 (26) |
| >15 | 137 (21) |
| Male sex | 365 (57) |
| Performance score | |
| <90 | 111 (17) |
| 90-100 | 513 (80) |
| Unknown | 14 ( 2) |
| Disease | |
| AML | 168 (26) |
| ALL | 329 (52) |
| CML | 75 (12) |
| MDS | 66 (10) |
| Disease status at transplanta | |
| Early | 175 (27) |
| Intermediate | 310 (49) |
| Advanced | 128 (20) |
| Otherb | 25 (4) |
| Donor age, median (range), years | 36 (19-60) |
| Donor age, years | |
| 18-30 | 169 (26) |
| 31-40 | 240 (38) |
| 41-60 | 229 (36) |
| Donor-recipient sex match | |
| Male -> Male | 230 (36) |
| Male -> Female | 132 (21) |
| Female -> Male | 135 (21) |
| Female -> Female | 141 (22) |
| Donor-recipient CMV match | |
| D(−)/R(−) | 277 (43) |
| D(−)/R(+) | 136 (21) |
| D(+)/R(−) | 125 (20) |
| D(+)/R(+) | 88 (14) |
| Unknown | 12 ( 2) |
| Donor pregnancy | |
| Male donor | 362 (57) |
| Female, no pregnancy | 117 (18) |
| 1 or more pregnancies | 153 (24) |
| Unknown | 6 ( 1) |
| Conditioning regimen | |
| Cy+TBI+/−other | 543 (85) |
| TBI+other | 29 ( 5) |
| Bu+Cy+/−other | 57 ( 9) |
| Bu+/other | 9 ( 1) |
| GVHD prophylaxis | |
| T-cell depletion | 234 (37) |
| CSA+MTX+/−other | 338 (53) |
| CSA+/−other | 18 ( 3) |
| FK506+/−other | 46 ( 7) |
| MTX+/−other | 1 (<1) |
| Missing | 1 (<1) |
| HLA match | |
| Matched | 296 (46) |
| Single allele mismatch | 84 (13) |
| Single antigen mismatch | 258 (40) |
| Median follow-up of survivors, months | 87 (3-195) |
a
Risk groups are defined as: Early - includes AML or ALL in CR1; CML in CP1; or MDS with RA or RARS; Intermediate - includes AML or ALL in ≥ CR2; CML accelerated phase or ≥CP2 and advanced - includes AML or ALL in relapse or PIF; CML in blast phase or MDS with RAEB-T or IPSS-4.
b
Other includes (N=25): 1) ALL, disease status prior to transplant is missing (n=1) 2) MDS, NOS (n=3) 3) CMML Chronic myelomonocytic leukemia (n=3) 4) PNH Paroxysmal nocturnal hemoglobinuria (n=1)