Table 3.
Multivariate analysis for relapse in children who were diagnosed with ALL (N=311) and received unrelated donor BMT.
| Variables | N | Odds Ratio (95% Confidence Interval ) |
P-value |
|---|---|---|---|
| HLA matching | |||
| Matched | 147 | 1.00 | |
| 7/8 matched | 164 | 0.72 (0.37, 1.43) | 0.45 |
| Grade III-IV aGVHD | |||
| No | 168 | 1.00 | |
| Yes | 143 | 0.34 (0.13, 0.86) | 0.0052 |
| Disease stage | 0.0012 | ||
| Early | 62 | 1.00 | |
| Intermediate | 214 | 1.96 (0.74, 5.17) | 0.17 |
| Advanced | 35 | 12.77 (3.83, 42.55) | < 0.0001 |
| Recipient age categories | 0.05 | ||
| < 5 years | 67 | 1.00 | |
| 6-10 years | 114 | 0.38 (0.17, 0.89) | 0.025 |
| 11-15 years | 75 | 0.22 (0.07, 0.66) | 0.0069 |
| 16-17.9 years | 55 | 0.31 (0.11, 0.87) | 0.025 |
| Transplant year group | |||
| 1999 - 2003 | 113 | 1.00 a | |
| 1990 - 1998 | 198 | 0.51 (0.26, 1.01) | 0.054 |