Figure 2. Physiological and pathophysiological responses mediated by Nox homologues in cardiovascular cells.
This summary of the roles of Nox enzymes in different cell types of the cardiovascular system illustrates the paradox of their mediating both specialized and redundant functions. VSMC, vascular smooth muscle cells; EC, endothelial cells; FB, fibroblasts; CM, cardiomyocytes, MΦ, macrophages; and EPC, endothelial progenitor cells.