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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Eur J Med Chem. 2012 Jan 15;49:200–210. doi: 10.1016/j.ejmech.2012.01.012

Fig. 5.

Fig. 5

Serotonin transporter (SERT) models based on the X-ray structure of the LeuTAa from Aquifex aeolicus: (a) the substrate-occluded conformation, (b) the outward-facing conformation. The models are coloured from amino (red) to carboxy (blue) terminal. Binding pockets identified by using ICM PocketFinder: putative binding pocket is displayed in orange color, vestibular binding pocket, consisting of the two subpockets, is displayed in a blue and pink color. The large binding pocket of SERT in the outward-facing conformation is displayed in red color.