Table 1.
Bioactive lysophospholipids
| LysoPLs | Cellular effect | Responding cell | Receptor | Ref |
|---|---|---|---|---|
| S1P | Survival | T-cells; B-cells; Macrophage | S1P1-2,4 | [3] |
| Migration | T-cells; B-cells, Mast cells; Macrophages; Dendritic cells | S1P1 | “ | |
| Angiogenesis | Endothelial cells | S1P1 | “ | |
| LPA | Migration | T-cells; Dendritic cells; Fibroblasts | LPA1-3 | [1] |
| Proliferation | Neuronal cells; Astrocytes | LPA1-2 | “ | |
| Survival | Neuronal cells; Endothelial cells; Leukocytes | LPA1-2 | “ | |
| LysoPC | Calcium mobilization | Neutrophils | G2A | [35] |
| T-cells | G2A ? | [77] | ||
| Enhance ROS | Neutrophil | ? | [19, 78] | |
| Inhibit ROS | Neutrophil | G2A | [79] | |
| Migration | T-cells; Monocytes | G2A | [54, 80, 81] | |
| LysoPS | Degranulation | Mast cells; Neutrophils | GPR34; G2A | [35, 42] |
| Enhance ROS | Neutrophil | ? | [19, 78] | |
| Calcium mobilization | Neutrophils; T-cells | G2A; ? | [35, 82] | |
| Leukemic cells | ? | [83] | ||
| Enhanced efferocytosis | Macrophages | G2A | [22, 23] | |
| Migration | Fibroblasts | ? | [17] | |
| Glioma cells | ? | [16] | ||
| Differentiation | PC12 | ? | [84] | |
| LysoPE | Calcium mobilization | Neutrophils | G2A | [35] |
| Migration | Ovarian cancer cells | ? | [85] |