Table 2.
Univariate Sensitivity Analysis Results – Assumptions Changing Cost-Effectiveness By At Least +/− 20%
| Assumptions | Favorable CE Ratios | Unfavorable CE Ratios | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Base Case | For Favorable CE Ratio | For Unfavorable CE Ratio | Inc. Cost | Inc. Discounted LY | Inc. CE | Inc. Cost | Inc. Discounted LY | Inc. CE | |
| Screening Prior to Stimulant Treatment for ADHD (Age 8) | |||||||||
| Base case | $170 | 8.3X10−4 | $203,979 | $170 | 8.3X10−4 | $203,979 | |||
| All SCD - RR with ADHD meds | 1.4 | 6.6 | 1.0 | $170 | 2.5X10−3 | $67,158 | $170 | 5.1X10−4 | $331,496 |
| HCM - Mortality ratea | 10 | 20 | 2 | $168 | 1.1X10−3 | $154,628 | $171 | 6.3X10−4 | $270,773 |
| HCM - Prevalencea | 45 | 300 | 45 | $268 | 2.3X10−3 | $115,781 | $170 | 8.3X10−4 | $203,979 |
| HCM - Community screening specificity | 85% | 100% | 85% | $103 | 8.3X10−4 | $123,444 | $170 | 8.3X10−4 | $203,979 |
| WPW - Mortality ratea | 1 | 5 | 0.5 | $169 | 2.7X10−3 | $62,729 | $170 | 5.5X10−4 | $309,959 |
| WPW - Prevalencea | 136 | 400 | 136 | $226 | 1.7X10−3 | $132,935 | $170 | 8.3X10−4 | $203,979 |
| LQTS - Prevalencea | 7 | 60 | 7 | $201 | 1.8X10−3 | $119,229 | $170 | 8.3X10−4 | $203,979 |
| Cost - Community based screen | $50 | $13 | $100 | $136 | 8.3X10−4 | $163,691 | $237 | 8.3X10−4 | $284,334 |
| Cost - Cardiology visit | $195 | $107 | $299 | $157 | 8.3X10−4 | $188,682 | $208 | 8.3X10−4 | $249,800 |
| Cost - Annual follow-up after ICD implantation | $14,533 | $357 | $206,000 | $161 | 8.3X10−4 | $193,710 | $704 | 8.3X10−4 | $846,429 |
| Screening Prior to Sports Participation (Age 14) | |||||||||
| Base case | $171 | 1.9X10−3 | $90,828 | $171 | 1.9X10−3 | $90,828 | |||
| All SCD - RR with sports participation | 2.8 | 3.8 | 1.0 | $171 | 2.5X10−3 | $67,495 | $170 | 3.0X10−4 | $574,711 |
| HCM - Prevalencea | 45 | 300 | 45 | $354 | 8.6X10−3 | $41,221 | $171 | 1.9X10−3 | $90,828 |
| WPW - Mortality ratea | 1 | 5 | 0.5 | $171 | 4.1X10−3 | $42,176 | $171 | 1.9X10−3 | $90,828 |
| Cost - HCM medication therapy (per year) | $805 | $0 | $13,000 | $172 | 1.9X10−3 | $91,326 | $222 | 1.9X10−3 | $117,787 |
| Cost - Cardiology visit | $195 | $107 | $299 | $153 | 1.9X10−3 | $81,337 | $210 | 1.9X10−3 | $111,914 |
| Cost - Annual follow-up after ICD implantation | $14,533 | $357 | $206,000 | $159 | 1.9X10−3 | $84,563 | $848 | 1.9X10−3 | $451,006 |
Abbreviations: CE, cost effectiveness; HCM, hypertrophic cardiomyopathy; ICD; implantable cardioveter defibrillator; Inc., incremental; LQTS, long QT syndrome; LY, life year; RR, relative risk; SCD, Sudden cardiac death; WPW, Wolff-Parkinson-White Syndrome.
a
Per 100,000 person year