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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Lab Invest. 2012 Mar 26;92(6):827–841. doi: 10.1038/labinvest.2012.53

Figure 10. A simplified action model of AGEs and curcumin in regulating the activation of HSCs.

Figure 10

AGEs stimulated HSC activation, which was eliminated by curcumin by inducing expression of AGE-R1 gene. The process was likely mediated by inhibiting ERK activity, inducing gene expression of PPARγ and sequentially stimulating its trans-activity. “↑” or “↓” indicates the effect of AGEs.